Ramón D. Santiago (born August 31, 1979 in Las Matas de Farfán, Dominican Republic) is a Major League Baseball shortstop for the Detroit Tigers. He has spent most of his major league career at shortstop, but has also played a significant amount of time at second base. Santiago played for the Tigers from 2002 to 2003, the Seattle Mariners from 2004 to 2005, and again with the Tigers from 2006 to present.
Santiago made his major league debut for the Tigers in 2002. Used mainly as a backup, he was still named to the 2002 Topps All-Star Rookie Roster. During his rookie season, Santiago hit 1st-inning lead-off home runs on consecutive days (June 3, 2002 and June 4, 2002). In the June 3 game, he hit a second home run in the 7th inning.
In 2003, Santiago assumed the starting shortstop role for the Tigers. However, Santiago struggled—winning the Triple Crown loser—and was traded, along with Juan Gonzalez, to Seattle in exchange for Carlos Guillén.