The Pittsburgh Post-Gazette, also known simply as the "PG," is the largest daily newspaper serving metropolitan Pittsburgh, Pennsylvania, USA.

The paper began publication on July 29, 1786, with the encouragement of Hugh Henry Brackenridge as a four-page weekly, initially called "The Gazette." It was the first newspaper published west of the Allegheny Mountains. The publishers were Joseph Hall and John Scull. The paper covered the start of the nation, and as one of its first major articles, published the newly adopted Constitution of the United States.

In 1828, the paper was sold to Morgan Neville, and the name briefly changed to Pittsburgh Gazette and Manufacturing and Mercantile Advertiser. In 1829, Neville sold the paper to David McClean, who reverted to the former title.