Breast cancer drug promising

NEW YORK, Feb. 27 (UPI) -- An anti-copper drug compound that disables bone marrow cells from receiving migrating cancer tumor cells may curb the spread of cancer, U.S researchers say.

Drug to shrink ovarian tumors promising

PHOENIX, Feb. 18 (UPI) -- Many women with low-grade carcinoma of the ovary have seen their tumors stabilize or shrink after using the drug selumetinib, U.S. researchers said.

BAE gets Phase II Bradley upgrade award

ARLINGTON, Va., Oct. 4 (UPI) -- The U.S. Army has given BAE Systems a $55 million, Phase II contract for engineering changes to Bradley Fighting Vehicles.

Boeing continues helo improvement work

RIDLEY PARK, Pa., Aug. 9 (UPI) -- Boeing reports it has received a U.S. Army contract for continued development of technology to improve helicopter maneuverability and performance.

Northrop bio-sensors complete test

LINTHINCUM, Md., July 11 (UPI) -- Northrop Grumman's offering for a U.S. Department of Homeland Security sensor acquisition program has completed a rigorous field test.

Ethiopia embraces geothermal power

ADDIS ABABA, Ethiopia, July 5 (UPI) -- The Ethiopian Geological Survey wants to increase the country's geothermal power generation.

Army advances new carbine offering

BALTIMORE, May 4 (UPI) -- A new rifle built upon the M4 and M16 platform is being eyed by the U.S. Army as a possible replacement for the M4 carbine.

Saudi Aramco starts gas megaproject

RIYADH, Saudi Arabia, April 24 (UPI) -- A natural gas processing facility for the Karan natural gas field in Saudi Arabia was completed seven weeks ahead of schedule, the Saudi Arabian Oil Co. said.

Common cold drug for asthmatics in works

MELBOURNE, March 30 (UPI) -- Officials of the Australian drug maker Biota Holdings Ltd. said a Phase II clinical trial of an antiviral treated colds in people with asthma.

Malaria drug may help boost cancer therapy

VANCOUVER, British Columbia, Feb. 21 (UPI) -- Blocking autophagy -- the process of "self-eating" within cells -- might be a viable way to enhance cancer treatment effectiveness, U.S. researchers said.

New info system for first responders

TORRANCE, Calif., Feb. 6 (UPI) -- The U.S. Department of Homeland Security has a contracted technology systems integrator for Phase II development of a helmet display for first responders.
Bird-sized UAV developed

Bird-sized UAV developed

WASHINGTON, Feb. 21 (UPI) -- A bird-sized unmanned aerial vehicle that flaps wings for propulsion and hovering has been developed by the U.S. company AeroVironment, Inc.

Nord Stream seeks cash for Phase II

ZUG, Switzerland, Oct. 19 (UPI) -- The Nord Stream pipeline consortium expects a strong commitment from lenders for the second phase of the project, the chief financial officer said.

Teledyne to work on guided ordnance

THOUSAND OAKS, Calif., Oct. 15 (UPI) -- Teledyne Scientific & Imaging LLC has been contracted by the U.S. Defense Advanced Research Projects Agency to develop innovative guided ordnance technology.

Pratt & Whitney develops new technology

EAST HARTFORD, Conn., Oct. 13 (UPI) -- The U.S. Defense Advanced Research Projects Agency has charged Pratt & Whitney to develop Constant Volume Combustion engine technology.
Page 2 of 10
Phase II
Sen. John Rockefeller (D-WV) speaks on Phase II investigation of prewar intelligence at a press conference on Capitol Hill in Washington on November 4, 2005. (UPI/Photo Kevin Dietsch)

Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety (or more specifically, information about adverse drug reactions and adverse effects of other treatments) and efficacy data to be collected for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). These trials can take place only after satisfactory information has been gathered on the quality of the non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.

Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single center in one country to multicenter trials in multiple countries.

Due to the sizable cost a full series of clinical trials may incur, the burden of paying for all the necessary people and services is usually borne by the sponsor who may be a governmental organization, a pharmaceutical, or biotechnology company. Since the diversity of roles may exceed resources of the sponsor, often a clinical trial is managed by an outsourced partner such as a contract research organization or a clinical trials unit in the academic sector.

This article is licensed under the GNU Free Documentation License.
It uses material from the Wikipedia article "Phase II."
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