Patricia T. Arquette (born April 8, 1968) is an American actress currently starring in the supernatural drama Medium.

Arquette was born in Chicago, Illinois, and was raised in Virginia and California. She is the daughter of Brenda "Mardi" Olivia (née Nowak), an actress, poet, theater operator, activist, acting teacher and therapist; and actor Lewis Arquette. Arquette's paternal grandfather was comedian Cliff Arquette. Arquette's mother was Jewish, the daughter of a Holocaust refugee from Poland, and Arquette's father was a convert to Islam and a descendant of explorer Meriwether Lewis. Arquette's siblings are actors Rosanna, Alexis, Richmond and David Arquette. Arquette is also the sister-in-law of Courteney Cox, who is married to her brother David.

In April 1987, Arquette married Nicolas Cage (with whom she would later co-star in Bringing Out the Dead in 1999). They separated after nine months, but acted as a couple in public until Cage filed for divorce in February 2000. The divorce petition was withdrawn, but Arquette filed again in November 2000.