The New Adventures of Old Christine is a comedy series starring Julia Louis-Dreyfus as a recently divorced single mother. The series debuted as a midseason replacement on March 13, 2006 on CBS and has broadcast four complete seasons. The sitcom is slated to return to CBS for a fifth season, to begin airing in September 2009. Old Christine, as it is often more conveniently called, is a Warner Bros. Television production and was created by writer Kari Lizer, who is also the show's executive producer.

In the show, Louis-Dreyfus stars as Christine Campbell, a neurotic divorced mother and owner of a women's gym who is in a constant struggle to keep pace with those around her. A frequent fixture in her life is her irresponsible ex-husband Richard (Clark Gregg) whose new girlfriend (Emily Rutherfurd) is also named Christine, hence the nickname "Old Christine" for the Louis-Dreyfus character. Christine lives with her son Richie and her brother Matthew (Hamish Linklater), while Wanda Sykes portrays Christine's best friend and colleague Barb. Christine also struggles with her inferiority complex with the snobby "meanie moms" (Alex Kapp Horner and Tricia O'Kelley) at her son's private school.

The show has featured recurring roles for a wide range of established actors including Blair Underwood, Dave Foley, Scott Bakula, Andy Richter and Jane Lynch.