Nicole Mitchell (also spelled Nikole, born 5 June 1974) is a retired Jamaican sprinter who specialized in the 100 metres. She also competed on the successful Jamaican team in the 4 x 100 metres relay, winning an Olympic bronze medal in 1996.

Her personal best time for 100 metres was 11.18 seconds, achieved in July 1993 in Kingston. She attended St. Mary's high school and she was always the best athlete, doing well in the 100m and 200m.