Matthew Thomas Cain (born October 1, 1984 in Dothan, Alabama) is a starting pitcher for the San Francisco Giants of Major League Baseball. He is 6 feet 3 inches (1.91 m) tall and weighs 235 pounds (107 kg).

Cain graduated from Houston High School in Germantown, Tennessee, where he earned the nickname "Big Sugar" and was selected by the Giants in the first round (25th overall) in the 2002 MLB Draft.

Prior to the 2005 season, Cain was named the #13 prospect in baseball by Baseball America. He features a fastball, curveball, slider, and changeup. His fastball is thrown from 93 to 98 mph.