Mary Claire Cheney (born March 14, 1969) is the second daughter of Dick Cheney, the former Vice President of the United States, and his wife, Lynne Cheney. Mary Claire Cheney, a lesbian, received a great amount of media attention in regards to her sexuality due to the Bush administration's views on gay marriage. She has an older sister, Elizabeth, who served as a Deputy Assistant Secretary of State, among several other federal government positions, during the Bush administration.

Cheney attended McLean High School in McLean, Virginia, graduating in the class of 1987. Following that, she attended Colorado College, her mother's alma mater, in Colorado Springs, Colorado and graduated in 1991. She earned a graduate business degree from the University of Denver in 2002.

In 1993, she became one of the first employees of the Colorado Rockies baseball team, working in promotions when the team began playing in Denver. Thereafter she was a public relations manager for the Coors Brewing Company and worked as a gay and lesbian outreach coordinator, helping to end a national gay boycott of Coors.