Maria Elena Bello (born April 18, 1967) is a Golden Globe-nominated American actress.

Bello was born in Norristown, Pennsylvania, the daughter of Kathy, a teacher and school nurse, and Joe Bello, a contractor. Her father is Italian American and her mother Polish American. She grew up in a working-class Roman Catholic family and graduated from Archbishop Carroll High School (Radnor, Pennsylvania). Later she attended Villanova University, majoring in political science. She intended to become a lawyer, but took an acting class during her senior year, just for fun. She was soon cast in small off-Broadway plays, such as The Killer Inside Me, Small Town Gals With Big Problems and Urban Planning. She later guest-starred on episodes of The Commish (1991), Nowhere Man (1995), Misery Loves Company (1995) and Due South (1994).

Bello's breakthrough came when the producers Kerry Lenhart and John J. Sakmar cast her as Mrs. Smith in the spy show Mr. & Mrs. Smith. The show was cancelled after just eight weeks on the air. Then came a guest stint on ER as the feisty pediatrician Dr. Anna Del Amico, in which she guest-starred in the final three episodes of the third season. Bello remained on the show for one season as a regular cast member, departing after the medical drama's 4th season. The actress went on into movies landing a role in Coyote Ugly. She has been nominated for the Golden Globe award twice: for Best Supporting Actress in The Cooler (2003) and for Best Actress in A History of Violence (2005). In 2008 Bello starred in The Mummy: Tomb of the Dragon Emperor as Eve O'Connell and in The Jane Austen Book Club as Jocelyn.