Manuel Uribe Garza (born June 11, 1965) is a man from Monterrey, Nuevo León, Mexico, and was one of the heaviest people in medical history. After reaching a peak weight of around 597 kg (1,316 lb) and being unable to leave his bed since 2001, Uribe lost considerable weight with the help of doctors and nutritionists, and by following the Zone diet.

Uribe drew worldwide attention when he appeared on the Televisa television network in January 2006, but turned down offers for gastric surgery in Italy.

In March 2007, Uribe set a goal to lower his weight to 120 kg (265 lb). Uribe has also been featured on "World's Heaviest Man", a television documentary about his bedridden life and attempts to lose weight.