Kelly Deane Melissa Rutherford (born November 6, 1968) is an American actress known for her roles of Stephanie "Sam" Whitmore on Generations, Megan Lewis on Melrose Place from 1996 to 1999 and Lily van der Woodsen on Gossip Girl from 2007 to the present.

In addition to her work on Generations and Melrose Place, Rutherford also starred in the early 1990s Homefront as Judy Owen, in 1995's The Great Defender as Frankie Collet, in 1996's Kindred: The Embraced as Caitlin Byrne, in 2003's Threat Matrix as Special Agent Frankie Ellroy Kilmer, and had a recurring role in The Adventures of Brisco County, Jr. as Dixie Cousins. She also had a small role on Scream 3 in 2000. Most recently, Rutherford starred as Samantha "Sonny" Liston, on the cancelled TV series E-Ring.

Rutherford currently stars as Lily van der Woodsen in the CW teen drama Gossip Girl.