José Enrique Serrano (born October 24, 1943) is a New York politician, currently representing the state's 16th congressional district (map) in the United States House of Representatives. His son, José M. Serrano, is a member of the New York State Senate.

Serrano's district is one of the smallest in the country geographically, consisting of a few miles of the heavily urbanized and populated South Bronx in New York City. His district is also one of the most densely populated and one of the few majority Hispanic districts in the country. Yankee Stadium is in his district. In addition to José Marco, Serrano has four other children.

Serrano was born in Mayagüez, Puerto Rico. At the age of seven, Serrano was taken by his family to The Bronx. Serrano went to high school and then attended Lehman College. He served in the United States Army medical corps from 1964 to 1966.