Jorge Luís Cantú Guzmán (born January 30, 1982, in McAllen, Texas) is a Major League Baseball first baseman for the Florida Marlins.

Cantú bats and throws right-handed. He was born in McAllen, Texas, and makes his home in nearby Reynosa, Tamaulipas, Mexico.

Cantú was spotted by a scout while playing in a Junior Olympic tournament in Mexico City while in high school, and offered a contract with the Tampa Bay Devil Rays at age 16. In 2003, Cantú played for the Mexican national team in the regional Olympic qualifying tournament. His team defeated the U.S. team, eliminating them from the 2004 summer games in Athens.