John Marcellus Huston (August 5, 1906 – August 28, 1987) was an American filmmaker, screenwriter and actor. He was known for directing the films The Maltese Falcon (1941), The Treasure of the Sierra Madre (1948), Key Largo (1948), The Asphalt Jungle (1950), The African Queen (1951), The Misfits (1960), and The Man Who Would Be King (1975). He was the son of actor Walter Huston and the father of actress Anjelica Huston and actor Danny Huston.

Huston (pronounced "Hew'-stun", like the city Houston) was born in Nevada, Missouri, the son of the Canadian-born actor, Walter Huston, and Rhea Gore, a sports reporter; he was of Scots-Irish descent on his father's side, his ancestral surname was Houston, and English and Welsh on his mother's. Huston was raised by his maternal grandparents, Adelia Richardson and John Marcellus Gore.

As a ten year old he was stricken by a serious illness which left him all but bedridden for several years. On his recuperation, this acted as the spur to pursue a full life, both intellectually and physically.