James Glasgow (c. 1735-1819) served as the first North Carolina Secretary of State, from 1777 to 1798. He resigned in disgrace after a scandal known as the "Glasgow Land Fraud."

The son of a Scottish minister, Glasgow was educated at William and Mary College. He was active in the revolutionary cause in North Carolina, and in December 1776, was rewarded by the last of the state's provincial congresses with the office of Secretary of State.

In 1791, while he was still serving as Secretary of State, the state legislature named a county after him, but after his resignation in disgrace, the county was renamed Greene County.