Isaac Isidore Bruce (born November 10, 1972 in Fort Lauderdale, Florida) is an American football wide receiver for the San Francisco 49ers of the National Football League. He was originally drafted by the Los Angeles Rams in the second round of the 1994 NFL Draft. He played college football at Memphis.

A an All-Pro and four-time Pro Bowl selection, Bruce has amassed 14,944 receiving yards in his career (second all-time). He played the first 14 years with the Rams and won a Super Bowl ring with the team in Super Bowl XXXIV.

Bruce, known as "Ike", was one of the most popular players on the St. Louis Rams. During player introductions and after big plays, it was custom for Rams fans to yell "Bruuuuuuce". To the uninitiated fan, it may sound like he is being booed.