Isaac Newton "Ike" Skelton IV (born December 20, 1931) is an American politician from the U.S. state of Missouri currently serving in the U.S. House of Representatives. A Democrat, he represents Missouri's 4th congressional district which takes in most of the western-central part of the state. The district is based in the state capital of Jefferson City and includes other cities such as Sedalia, Warrensburg, Marshall, and Lebanon.

Skelton currently serves as Chair of the House Armed Services Committee. He had previously served as Ranking Member on the committee since 1998 but was upped to chairman following Democrats regaining control of Congress after the midterm elections in 2006.

Skelton was born in Lexington, Missouri, where he still lives today.