George Lopez (born April 23, 1961) is a Mexican American comedian and actor. He is known for starring in his self-produced ABC sitcom George Lopez. His stand-up comedy examines race relations and the Mexican culture within the United States.

Lopez was born in Mission Hills, Los Angeles, California. He was deserted by his dad at birth and was then deserted by his mother at the age of 10 years old but was raised by his maternal grandmother, Benita Gutierrez, a factory worker, and step-grandfather Refugio Gutierrez, a builder. In 1993, Lopez married Ann Serrano. The couple has one child together (Mayan).

Lopez has a genetic condition that caused his kidneys to deteriorate; the congenital abnormality caused a narrowing of his ureters, the tubes through which urine travels from each kidney to the bladder. His doctors had told him in April 2004 that he was going to require an organ transplant but he postponed the operation until after finishing the 4th season of George Lopez so as not to hurt the 170 people who worked on his show. In 2005, his wife Ann donated one of her kidneys to Lopez. The transplant was successful; Lopez lost 45 lbs. after the operation due in part to having his health so vastly improved. He brought awareness to the issue on his show; his son, Max, was diagnosed with a similar illness.