George Jean Nathan (February 14, 1882 – April 8, 1958) was an American drama critic and editor.
Nathan was born in Fort Wayne, Indiana. He graduated from Cornell University in 1904, where he was a member of the Quill and Dagger society, and an editor of The Cornell Daily Sun.
Noted for the erudition and cynicism of his reviews, Nathan was an early champion of Eugene O'Neill. Together with H.L. Mencken, he co-edited the magazine The Smart Set from 1914 and co-founded The American Mercury in 1924. He was also a founder and an editor (1932–35) of the American Spectator, and after 1943 he wrote a syndicated column for the New York Journal-American. He also co-authored with Mencken (under the pseudonym of Owen Hatteras) the autobiographical Pistols for Two.