Ethel Barrymore (August 15, 1879 – June 18, 1959) was an American actress and a member of the famous Barrymore family.

Ethel Barrymore was born Ethel Mae Blythe in Philadelphia, Pennsylvania, the second child of the actors Maurice Barrymore (whose real name was Herbert Blythe) and Georgiana Drew. She spent her childhood in Philadelphia, and attended Roman Catholic schools there.

She was the sister of actors John Barrymore and Lionel Barrymore, the aunt of actor John Drew Barrymore, and the great-aunt of actress Drew Barrymore. She was also the niece of Broadway matinée idol John Drew Jr and early Vitagraph movie star Sidney Drew.