Ernesto Zedillo Ponce de León (born December 27, 1951) is a Mexican economist and politician. He served as President of Mexico from December 1, 1994 to November 30, 2000, as the last of the uninterrupted seventy year line of Mexican presidents from the National Revolutionary Party to the Institutional Revolutionary Party. Since the ending of his term as president in 2000, Zedillo has been a leading voice on globalization, especially its impact on relations between developed and developing nations.

He is currently Director of the Center for the Study of Globalization at Yale University.

Ernesto Zedillo was born on December 27, 1951 in Mexico City. His parents were Rodolfo Zedillo Castillo, a mechanic, and Martha Alicia Ponce de León. Seeking better job and education opportunities for his children, his parents moved to Mexicali, Baja California.