Enrico Fermi (29 September 1901 – 28 November 1954) was an Italian physicist most noted for his work on the development of the first nuclear reactor, and for his contributions to the development of quantum theory, nuclear and particle physics, and statistical mechanics. Fermi was awarded the Nobel Prize in Physics in 1938 for his work on induced radioactivity and is today regarded as one of the top scientists of the 20th century. He is acknowledged as a unique physicist who was highly accomplished in both theory and experiment. Fermium, a synthetic element created in 1952, the Fermi National Accelerator Lab, and a type of particles called fermions are named after him.

Enrico Fermi was born on September 29, 1901 in Rome, Italy to Alberto Fermi, a Chief Inspector of the Ministry of Communications, and Ida de Gattis, an elementary school teacher who built her own pressure cooker. As a young boy he enjoyed learning physics and mathematics and shared his interests with his older brother, Giulio. When Giulio died unexpectedly of a throat abscess in 1915, Enrico was distraught, and immersed himself in scientific study to distract himself. According to his own account, each day he would walk in front of the hospital where Giulio died until he became inured to the pain. One of the first sources for the study of physics was a book found at the local market of Campo de' Fiori in Roma. The 900 page book, entitled Elementorum physicae mathematicae, was written in Latin by Father Andrea Caraffa, a professor at the Collegio Romano, covered subjects like mathematics, classical mechanics, astronomy, optics, and acoustics. Notes found in the book indicate Fermi studied it intensely. Later, Enrico befriended another scientifically inclined student named Enrico Persico, and the two worked together on scientific projects such as building gyroscopes, and measuring the Earth's magnetic field. Fermi's interest in physics was further encouraged by a friend of his father, Adolfo Amidei, who gave him several books on physics and mathematics, which he read and quickly assimilated.

In 1918 Fermi enrolled at the Scuola Normale Superiore in Pisa, where he was later to receive his undergraduate and doctoral degree. In order to enter the Institute, candidates had to take an entrance exam which included an essay. For his essay on the given theme Characteristics of Sound, 17-year-old Fermi chose to derive and solve the Fourier analysis based partial differential equation for waves on a string. The examiner, Prof. Giulio Pittato, interviewed Fermi and concluded that his essay would have been commendable even for a doctoral degree. Enrico Fermi ended up at the first place in the classification of the entrance exam. During the years at the Scuola Normale Superiore, Fermi teamed up with a fellow student named Franco Rasetti with whom he used to indulge in light-hearted pranks. Later, Rasetti became Fermi's close friend and collaborator.