Elizabeth Anania Edwards (born Mary Elizabeth Anania on July 3, 1949, in Jacksonville, Florida) is an attorney and the wife of John Edwards, a former U.S. Senator from North Carolina who was the 2004 United States Democratic vice-presidential nominee, and a candidate for the 2008 Democratic presidential nomination.

Elizabeth Anania is the daughter of Elizabeth and Vincent Anania (1920–2008), a United States Navy pilot. For part of her childhood she lived in Japan, where her father was stationed. She attended Mary Washington College and then transferred to the University of North Carolina at Chapel Hill. She received her bachelor's degree from UNC, and also performed three years of postgraduate study in English there. She then entered UNC's School of Law and earned a J.D. She met John Edwards when they were both law students at UNC. They married on July 30, 1977.

Elizabeth and John Edwards are the parents of four children: Wade, Catharine, Emma Claire, and Jack. Wade was killed in April 1996 when he lost control of his Jeep while driving from his Raleigh home to the family's beach house on the private gated community of Figure Eight Island, near Wilmington . Three weeks before his death, Wade Edwards was honored by First Lady Hillary Rodham Clinton at the White House as one of the 10 finalists in an essay contest sponsored by the National Endowment for the Humanities and the Voice of America. Wade, accompanied by his parents and sister, met North Carolina Sen. Jesse Helms. After he died, Helms entered Wade's essay and his obituary into the Congressional Record .