Dera Ismail Khan (Pashto: ډیرہ اسماعیل خان) is a city in North West Frontier Province, Pakistan. The town, the headquarters of Dera Ismail Khan District, is situated on the west bank of the Indus River and lies 200 miles west of Lahore and 120 miles north-west of Multan. The city is the headquarters of the district and tehsil of the same name, in Pakistan, it is often abbreviated to D.I.Khan.
Dera Ismail Khan was founded towards the end of the fifteenth century by Ismail Khan, a son of the Baloch adventurer Malik Sohrab, who named the town after himself. Dera means settlement or abode. The original town was swept away by a flood in 1823, and the existing buildings are all of quite modern construction, the present town stands four miles back from the permanent channel of the river.
The descendants of Malik Sohrab, who settled there after migrating from Iraq, ruled the city for 300 years.