Dean D. Pregerson (born 1951) is a United States federal judge.

Pregerson was born in Los Angeles, California. He received a B.A. from the University of California, Los Angeles in 1972. He received a J.D. from the University of California, Davis School of Law in 1976. He was a Parole hearing officer, Department of Corrections, State of California in 1977. He was in private practice in Ventura, California in 1978. He was an Assistant public defender, Public Defender Service Corporation, Agana, Guam from 1978 to 1981. He was in private practice in Agana, Guam in 1982. He was in private practice in Napa, California in 1982. He was in private practice in Los Angeles, California from 1983 to 1985. He was a Vice president and general counsel, The Torrance Company, California in 1985. He was in private practice in Los Angeles, California from 1986 to 1996.

Pregerson is a federal judge on the United States District Court for the Central District of California. Pregerson was nominated by President Bill Clinton on January 26, 1996, to a seat vacated by A. Wallace Tashima. He was confirmed by the United States Senate on July 24, 1996, and received his commission on August 1, 1996.