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Topic: David Sinclair

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Declining vaccination rates put Texas in danger of measles outbreaks, study says

Health News // 4 years ago

Declining vaccination rates put Texas in danger of measles outbreaks, study says

At current vaccination rates, a simulation estimates that measles outbreaks of more than 400 cases could occur in Austin and Dallas-Fort Worth.

Health News // 1 decade ago

Fountain of youth or at least delayed aging may be possible

U.S. and Australian researchers say the cause of aging in mammals may be reversible and the key is the chemical NAD that facilitates cell communication.

Health News // 1 decade ago

Harvard researcher quits Shaklee

A Harvard professor and the California-based Shaklee Corp. differ on whether he approved the use of his name to promote a purportedly life-extending syrup.

Odd News // 1 decade ago

Drunken Australian rousts couple from room

A vacationing Australian sheep shearer has admitted breaking into the hotel room in Scotland where a Swedish couple were sleeping.

Health News // 1 decade ago

Resveratrol seen to boost quality of life

A compound found in red wine -- resveratrol -- was found to improve the quality of life of aging mice, but not lengthen their lives, U.S. researchers said.

Science News // 1 decade ago

Aging, neurodegenerative link found

U.S. scientists have discovered a specific gene provides a link between aging and neurodegenerative disorders.

Science News // 1 decade ago

Caution urged with resveratrol

A scientist at the Mayo Clinic in Rochester, Minn., says there is no evidence a popular supplement has the same effect in humans as it does in mice.

Science News // 1 decade ago

Resveratrol test produces good results

U.S. researchers say feeding middle-aged mice a high-calorie diet with a compound found in red wine improves their health and extends their lifespan.

Science News // 1 decade ago

Study: New lifespan extension genes found

Researchers at the Harvard Medical School in New Haven, Conn., and the University of California-Davis report finding new genes tied to lifespan.

Science News // 2 decades ago

Red wine ingredient may extend life

The fountain of youth may spring from a glass of red wine, at least for yeast, the toast of human aging research.

Quotes

He had far too much to drink. He remembers drinking whiskey and that's not normally his drink
Drunken Australian rousts couple from room Aug 01, 2008

If we are successful in developing drugs that mimic (calorie restriction), we would expect maximum as well as average lifespan to increase also
Red wine ingredient may extend life Aug 27, 2003

In the past few years, a new paradigm in aging research has emerged -- that aging can be regulated
Red wine ingredient may extend life Aug 27, 2003

It is too early to say whether we will be successful in our goal to slow or prevent diseases of old age
Red wine ingredient may extend life Aug 27, 2003

David A. Sinclair PhD is a biologist best known for his research on the biology of lifespan extension and driving research towards treating diseases of ageing.

Sinclair is Professor of Pathology and Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Dr. Sinclair obtained a Bachelors of Science (Honors Class I) at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at MIT with Leonard Guarente before being recruited in 1999 to Harvard Medical School.

One of Sinclair's discoveries was in the lab of Leonard Guarente where he identified the key role of rDNA circles or "ERCs" in determining the lifespan of yeast. ERCs were subsequently shown to be suppressed by the SIR2 gene, the founding member of the sirtuin gene family, as well as deletion of the FOB1 gene. With Kevin Mills and Lenny Guarente, he also showed that the Sir2 protein relocalizes to DNA breaks and mediates repair. These two discoveries led his lab to discover that genomic instability induces changes in gene regulation may drive the aging process in mammals.

FULL ARTICLE AT WIKIPEDIA.ORG

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It uses material from the Wikipedia article "David Sinclair."