David A. Sinclair PhD is a biologist best known for his research on the biology of lifespan extension and driving research towards treating diseases of ageing.
Sinclair is Professor of Pathology and Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Dr. Sinclair obtained a Bachelors of Science (Honors Class I) at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at MIT with Leonard Guarente before being recruited in 1999 to Harvard Medical School.
One of Sinclair's discoveries was in the lab of Leonard Guarente where he identified the key role of rDNA circles or "ERCs" in determining the lifespan of yeast. ERCs were subsequently shown to be suppressed by the SIR2 gene, the founding member of the sirtuin gene family, as well as deletion of the FOB1 gene. With Kevin Mills and Lenny Guarente, he also showed that the Sir2 protein relocalizes to DNA breaks and mediates repair. These two discoveries led his lab to discover that genomic instability induces changes in gene regulation may drive the aging process in mammals.