Fountain of youth or at least delayed aging may be possible

BOSTON, Dec. 22 (UPI) -- U.S. and Australian researchers say the cause of aging in mammals may be reversible and the key is the chemical NAD that facilitates cell communication.

Harvard researcher quits Shaklee

CAMBRIDGE, Mass., Dec. 26 (UPI) -- A Harvard professor and the California-based Shaklee Corp. differ on whether he approved the use of his name to promote a purportedly life-extending syrup.

Drunken Australian rousts couple from room

PERTH, Scotland, Aug. 1 (UPI) -- A vacationing Australian sheep shearer has admitted breaking into the hotel room in Scotland where a Swedish couple were sleeping.

Resveratrol seen to boost quality of life

BOSTON, July 3 (UPI) -- A compound found in red wine -- resveratrol -- was found to improve the quality of life of aging mice, but not lengthen their lives, U.S. researchers said.

Aging, neurodegenerative link found

CAMBRIDGE, Mass., July 10 (UPI) -- U.S. scientists have discovered a specific gene provides a link between aging and neurodegenerative disorders.

Caution urged with resveratrol

ROCHESTER, Minn., Nov. 30 (UPI) -- A scientist at the Mayo Clinic in Rochester, Minn., says there is no evidence a popular supplement has the same effect in humans as it does in mice.

Resveratrol test produces good results

BOSTON, Nov. 1 (UPI) -- U.S. researchers say feeding middle-aged mice a high-calorie diet with a compound found in red wine improves their health and extends their lifespan.

Study: New lifespan extension genes found

NEW HAVEN, Conn., Sept. 29 (UPI) -- Researchers at the Harvard Medical School in New Haven, Conn., and the University of California-Davis report finding new genes tied to lifespan.

Red wine ingredient may extend life

SAN FRANCISCO, Aug. 27 (UPI) -- The fountain of youth may spring from a glass of red wine, at least for yeast, the toast of human aging research.
LIDIA WASOWICZ, UPI Senior Science Writer

David A. Sinclair PhD is a biologist best known for his research on the biology of lifespan extension and driving research towards treating diseases of ageing.

Sinclair is Professor of Pathology and Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Dr. Sinclair obtained a Bachelors of Science (Honors Class I) at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at MIT with Leonard Guarente before being recruited in 1999 to Harvard Medical School.

One of Sinclair's discoveries was in the lab of Leonard Guarente where he identified the key role of rDNA circles or "ERCs" in determining the lifespan of yeast. ERCs were subsequently shown to be suppressed by the SIR2 gene, the founding member of the sirtuin gene family, as well as deletion of the FOB1 gene. With Kevin Mills and Lenny Guarente, he also showed that the Sir2 protein relocalizes to DNA breaks and mediates repair. These two discoveries led his lab to discover that genomic instability induces changes in gene regulation may drive the aging process in mammals.

This article is licensed under the GNU Free Documentation License.
It uses material from the Wikipedia article "David Sinclair."
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