Charles Nelson Manning (born March 31, 1979 in Winter Haven, Florida) is Major League Baseball relief pitcher for the St. Louis Cardinals. He went to the University of Tampa and is 6'2 and weighs 180 pounds. Manning throws and bats left-handed.

Manning was selected in the 9th round by the New York Yankees of the 2001 Major League Baseball Draft. On July 31, 2003, Manning was traded to the Cincinnati Reds with Brandon Claussen for Aaron Boone. The Yankees re-acquired him on June 18, 2004, for Gabe White. Manning was a 2006 Eastern League Mid-Season All-Star. He spent the 2007 season with Double-A Trenton and Triple-A Scranton.

Manning became a minor league free agent after the 2007 season and signed with the Washington Nationals. On May 23, 2008, the Nationals called Manning up from Triple-A Columbus.