Brian Douglas Shouse (born September 26, 1968 in Effingham, Illinois) is a left-handed relief pitcher in Major League Baseball with the Tampa Bay Rays. Since 2001, Shouse has pitched with a distinctive sidearm delivery, which replaced his earlier, more traditional, overhand delivery.

Shouse played college baseball at Bradley University in Peoria, Illinois from 1987 until 1990, when he signed with the Pirates after being drafted in the 13th round of the 1990 Major League Baseball Draft. He is in the Bradley Braves Hall of Fame.

Shouse made his Major League debut in 1993, appearing in 6 games that season for the Pittsburgh Pirates. He did not appear in the major leagues again after that season until 1998, with the Boston Red Sox. Again, Shouse would experience a long drought from the major leagues after 1998; his next MLB appearance was in 2002 with the Kansas City Royals.