William A. Donohue (born July 18, 1947 in Manhattan, New York), has been the president of the Catholic League for Religious and Civil Rights in the United States since 1993. It claims to be the largest Catholic civil rights organization in the United States. He is known for his public statements on matters that the Catholic League believes relate to the defamation of and the civil rights of Catholics in particular and Christians in general.

William A. Donohue began his teaching career in the 1970s working at St. Lucy's School in Spanish Harlem. In 1977, he took a position as a college professor teaching at La Roche College in McCandless, Pennsylvania. In 1980 he received a doctorate in Sociology from New York University (NYU).

His first book was The Politics of the American Civil Liberties Union and he became associated with the conservative Heritage Foundation where he is an adjunct scholar. His books on the ACLU made him one of the group's most prominent critics and firebrands.