Anne Elizabeth "Annie" Darwin (2 March 1841–23 April 1851) was the second child and eldest daughter of Charles and Emma Darwin. According to biographers, she was a delightful child who brought much happiness to her parents. Eminent Darwin scholar E. Janet Browne writes of her:
In 1849, Anne caught scarlet fever along with her two sisters, and her health thereafter declined; some authorities believe that she suffered from tuberculosis. In vain pursuit of help from Gully's water cure, Charles Darwin took his daughter to the Worcestershire spa town, Great Malvern. She died in Montreal House on the Worcester Road, and is buried in the Great Malvern Priory Church yard.
Her death at age ten was a terrible blow for both Charles and Emma. Charles wrote in a personal memoir "We have lost the joy of the household, and the solace of our old age ... Oh that she could now know how deeply, how tenderly we do still & and shall ever love her dear joyous face.".