Alexi Casilla Lora (born July 20, 1984 in San Cristobal, Dominican Republic) is a Major League Baseball second baseman for the Minnesota Twins. He wears number 25 and is a switch-hitter.

Casilla was signed as a free agent by the Los Angeles Angels in 2003. On December 9, 2005, the Angels traded Casilla to the Minnesota Twins for pitcher J.C. Romero. Casilla made his major league debut with the Twins in September of 2006, playing in 9 games.

In 2007, after a brief callup with the Twins, Casilla became the every-day second baseman after Luis Castillo was traded to the New York Mets. Casilla struggled, producing a .222 batting average with no home runs in 189 at-bats.