Sangamo BioSciences is engaged in the research, development, and commercialization of DNA-binding proteins for the therapeutic regulation and modification of disease-related genes. Co. has a proprietary technology platform that is based on the engineering of a naturally occurring class of proteins referred to as zinc finger DNA-binding proteins (ZFPs). Also, ZFPs may be engineered to create zinc finger nucleases, or ZFNs , which can be used to cut genomic DNA at a pre-selected sequence location, enabling ZFN-mediated disruption of genes that are responsible for disease pathology, correction of genes that contain disease-causing mutations, or the targeted addition of a selected DNA sequence.
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