The racing star's account reached the milestone in the days prior to Sunday's Daytona 500.
Patrick, 28, is a polarizing figure in the racing world. She has a number of loyal supporters and is popular among casual fans, but has also received harsh criticism in the past from NASCAR die-hards who question her merit as a driver.
Patrick is the undisputed leader when compared to her fellow NASCAR drivers on Twitter. She has more than twice as many followers as six-time champion Jimmie Johnson, who comes in second amongst drivers at 541,000.
Patrick finished in 40th place on Sunday after being involved in a multi-car wreck during the race. No one was seriously injured.