The 39-year-old former Sugarland member released her first solo album, That Girl, in January. Her appearance at the Hard Rock Hotel & Casino Friday is the second stop of her tour to promote the record.
Nettles will begin her tour at the Ryman Auditorium in Nashville, Tennessee, on February 20.
Nettles' show in Biloxi will be followed by "Masters of Illusion" -- "a touring magic show based on the award-winning winning TV series" -- who are set to perform Saturday. On the same day, Bennett will perform at Beau Rivage, and Jimmy Buffett's Margaritaville Biloxi will present "Simply the Best," an homage to Tina Turner.