The police procedural drama is set to air in the spring. The two-part pilot centers on the NCIS New Orleans office which handles cases from the Florida panhandle through Mississippi and Louisiana to the Texas panhandle.
Pounder is set to play Dr. Wade, the eccentric and smart Jefferson Parish Medical Examiner.
NCIS showrunner Gary Glasberg and star Mark Harmon will executive produce the spinoff.
Pounder is best known for her roles in FX's Sons of Anarchy, Warehouse 13, Brothers and ER.