NATO released a statement following the crash: "International Security Assistance Force service members and one ISAF civilian died following an aircraft mishap in eastern Afghanistan today."
According to a defense official interviewed by ABC News, the MC-12 reconnaissance aircraft crashed while conducting a nighttime mission in eastern Afghanistan.
Friday's crash follows two deadly helicopter crashes this week. On Wednesday, a Navy helicopter crashed off the coast of Norfolk, Virginia, killing two crew members and a third member presumed dead. On Tuesday, a U.S. Air Force helicopter crashed on the coast of Norfolk in England, killing four Air Force personnel.