Red carpet host Tim Gunn challenged the actress, who was making her first ever appearance at the People's Choice Awards, to play a game matching a tray full of paper bones to Gunn's real body.
"You're good!" exclaimed an impressed Gunn.
And when Deschanel worried about ruining the impeccably-dressed Gunn's outfit, he told her not to worry.
"Emily, you can do whatever you want to me," he joked.