"Now a lot of people think that this is a fight that has been fought and already won, or that AIDS is only a problem in other countries, or that Matthew McConaughey and Jared Leto cured AIDS down in Texas... but they didn't," she joked. "Too soon?"
Handler donated $100,000 of her own money before the auction even began, while honoree Aileen Getty and her sister tossed in $1 million each.
"I'm going to give $100,000," Handler said. "I hate going to these things -- you get a little buzz going and then whoopsy! I have a traveler's check in my car."
Celebrity Breakups and divorces of 2014 [PHOTOS]