The issue, which hits newsstands December 6, features an 18-page pictorial and interview with the famous Brit.
Appropriately for an anniversary edition, Moss, 39, reminisces about her own beginnings.
"I was, like, a child when I started. I was 14," she said. "If it hadn't happened, I don't know what would have happened to me. I would be in Croydon (the neighborhood south of London where she grew up), working in a bar, probably."
Flip through the gallery, above, to see the images released ahead of the issue.
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