The cause or location of the Velvet Underground frontman's death wasn't immediately reported, though he underwent a liver transplant in May.
Fellow musicians and actors alike expressed their shock and sympathies over the death of the "Walk on the Wilde Side" musician.
Devastating news:... http://t.co/LukCOL1T4r— Iggy Pop (@IggyPop) October 27, 2013
R.I.P. Lou Reed. Just met at the GQ Awards. The music of my generation. Still Relevant!— Samuel L. Jackson (@SamuelLJackson) October 27, 2013
Lou Reed RIP - always inspired by him - terrible news - only knew him through his art -a great - a singular poet -— John Cusack (@johncusack) October 27, 2013
Notable deaths of 2014 [PHOTOS]