The Great Dane was 3 feet, 7 inches from paw to shoulder and nearly 7 feet long and was well known for his appearances on television shows like "Live with Regis & Kelly" and "Good Morning America."
The cause of George's death wasn't reported.
"It is with a heavy heart that we announce Giant George died on Thursday, October 17, 2013. George passed away peacefully surrounded by loved ones; one month before his eighth birthday," George's owners said on his website, GiantGeorge.com. "We appreciate the love and support you have given Giant George over the last several years. We look forward to honoring his spirit by continuing his charitable works. Your thoughts and prayers are much appreciated."