"It's been wonderful guys. I've decided to leave #RHONJ this season was my last. Love and kisses to you all. xoxoxo," Manzo tweeted immediately after this season's Sunday finale.
Manzo, a 52-year-old mom of three, explained her decision to leave on Bravo's "Real Housewives" blog.
"Over the past few years my outlook on the show has changed from something I couldn't wait to show my future grandchildren to something I hope my future grandchildren never see," she wrote. "Going back to film another season of Housewives would only make me a hypocrite."
Manzo spent her last few years on the show battling it out with Teresa Giudice, currently facing up to 50 years in prison on federal fraud charges.
"For me, peace and integrity cannot be bought with money or fame. I practice what I preach, and as I said on the reunion, I'm done.I simply feel that my role has run its course and I have nothing more to give," she added.
Manzo's announcement doesn't mean that she'll leave Bravo for good. She and her family are filming a pilot, "Manzo'd with Children," which will give fans a "very different" look at Caroline, her husband Al, and their three children.
"We are having an absolute blast filming it, and I hope you all join us as we start our new chapter within the Bravo newtork. We didn't close the book, we just turned the page," she wrote.