Rancic learned about her diagnosis after undergoing a mammogram that was required by her doctor before taking what would have been her third round of in-vitro fertilization.
After her diagnosis, Rancic had a double lumpectomy as part of her breast cancer treatment and later got a double mastectomy. Since then, the E! host has been undergoing periodical check ups.
"It's pretty much blood work every four months and they test everything to make sure I'm OK -- and so far, so good...That's really the monitoring I do. It's just regular doctors' appointments to make sure everything is OK," the 39-year-old said.
"I was very fortunate. Because I've gone public with the breast cancer, I hear a lot of stories and some are not as great as others. Whether it's resulting in complications from surgery...whatever the case. I hear it all. And I realize how fortunate I am...to have just kind of gotten out of there OK because it is such a major surgery."
About her double mastectomy, Rancic explained that many people come up to her thinking about getting one for themselves without really understanding the situation.
"I don't know what sort of message people are getting, but it's so important to know the facts," she said. "If you have breast cancer, it runs in your family or you have the gene and maybe you are thinking of having the surgery, talk to your doctor. Maybe it actually might make sense for you. But there are a lot of scenarios where a mastectomy would not make sense. So you have to make sure you're going to a good doctor, getting a second opinion, which was a big deal in my case, and just that you know what you're getting yourself into. It's not a glamorous surgery by any means."
She added that having husband Bill Rancic by her side had been key in her recovery.
"Bill was everything. My husband was everything throughout the process -- from getting diagnosed 'til today," she said. "And I don't know how I would have done it without him. I really don't...I always say not everyone has that support system. I can't even imagine having gone through breast cancer without having an incredible person by my side to help me through it."
Currently, Rancic has partnered with the Save Lids to Save Lives campaign from General Mills to help raise money for the Susan G. Komen Foundation.
"It's an incredible program. Over the past 15 years General Mills has donated $50 million to the fight against breast cancer, and that's a huge amount," said Rancic.