"Well, this is it. The last episode ever of Breaking Bad. Thank you for sharing this ride with me. Without you we never would have lasted," Cranston, who stars as Walter White, wrote early Sunday afternoon.
"Thanks for joining us on this crazy ride...what an amazing 6 years it's been. Big love to you all...and purple kisses," Brandt, who plays Walt's sister-in-law Marie Schrader tweeted.
Paul, who was hosting a benefit screening of the show at the Hollywood Forever Cemetery, also shared his thoughts on the social media site.
"Last episode ever of Breaking Bad. It would not be possible without all of you. Thank you all for the amazing ride. Love you Vince!!!!" he wrote.
RJ Mitte, who plays Cranston's son on the show, also thanked the fans via Twitter and urged them to continue their support.
"To all of you that are followers THANKS!" he wrote. "It ends tonight, But as actors we will all continue in other projects, please continue your support"