In an interview with Access Hollywood the 38-year-old star said she has no intention of walking down the aisle a third time.
"I've been married twice," said Longoria, who divorced Tyler Christopher in 2004 and Tony Parker in 2011. "Been there, done that!"
While on the subject of love, Longoria added that she believes children should be a "product of love" and that she's not one of those women who feel like they "must procreate."
"I think kids are a product of love," the star said. "So, if you find the right person and you want to have a family with that person, then that's when the time is right. But...if I'm 50 and single, I'm not going to go do it myself."
Asked about rumors that she's having a relationship with George Clooney, now that she's no longer dating Ernesto Arguello, Longoria said they weren't true.
"[Rumors] start all the time," she said. "Thank god it was a good one!"
In regards to how she keeps her youthful look, the "Desperate Housewives" star confessed she's not really afraid of aging.
"It's kind of irrelevant to me. I work out a lot, and I eat really well, and I just do that because I feel better," she said. "I'm not really overly concerned with it."
"I love aging, as far as getting wiser," Longoria added. "I have no desire to be 25 again. Maybe I want my 25-year-old body, but I don't want my 25-year-old mind!"
But would she go under the knife to get that old body back? Maybe.
"I am not opposed to surgery or whatever stuff is going to be available," she revealed. "Sign me up!"
Gal Gadot cast as Wonder Woman for 'Batman vs. Superman'
Beyonce flaunts bikini body, Blue Ivy in vacation pics