Monday night marks McCarthy's first show, joining Whoopi Goldberg, Sherri Shepherd and Barbara Walters for the premiere of Season 17 of the gab-fest.
McCarthy, 40, and Wahlberg, 44, went public with their relationship in July, after meeting when the New Kids on the Block singer paid a visit to McCarthy's VH1 show. Wahlberg is in the midst of promoting his show "Blue Bloods," which was recently renewed for its fourth season.
Also joining the ladies for the first show is musical guest Michael Buble, who welcomed his first son August 27.
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