Authorities said that the homeowner was cleaning out his shed when he found the 100-pound snake --probably somebody's lost pet.
"It was very nicely holed up in a shed, it's been there a while," Lt. Lisa Wood, of the Miami-Dade Fire Rescue Venom Unit, said of the reptile.
The man who found the python said it was munching on a cat's skull when he spotted it.
"Speaking with the neighbors, apparently there's a couple of rabbits and a cat missing from the neighborhood recently so the snake may be to blame for that," Wood added.
Though native to southeast Asia, burmese pythons were brought to Florida as pets and have since become an invasive species.