Aside from the long-running television series "Weeds," Parker will appear in two upcoming movies: "R.I.P.D." and "Red 2."
While apparently promoting "R.I.P.D." the 48-year-old actress said she's just "not really that into it anymore."
"I don't know how many more movies I wanna do," Parker said. "I wouldn't mind doing a TV show again, I'd like to do a couple more plays, but I'm almost done acting, I think."
But it isn't the work that has her down, it's "mean" comments on the Internet.
"The world has gotten too mean for me, it's just too b**chy. All the websites and all the blogging and all the people giving their opinion and their hatred … it's all so mean-spirited, it's all so critical.
"It's sport for people, it's fun to get on at night and unleash their own self-loathing by attacking someone else who they think has a happier life -- or something, I dunno."
She also says a retirement from acting is motivated by her desire to protect her children, a nine-year-old boy and six-year-old girl, from such a "mean culture."
Selena Gomez drops F-bomb, walks off stage during Jingle Ball performance
'SNL': 'Anchorman 2' cast, One Direction sing 'Afternoon Delight' [VIDEO]