The exchange came after Carlson asked Begala if he thought Clinton would run in 2016. Begala -- a former strategist for Bill Clinton's 1992 campaign said "she's actually gonna first live a life."
"Would she be a good president? No, she would be a great president," Begala said of Clinton. He went on to say the fact the Republicans were "afraid" of her was a good sign. As he began listing other things she'll probably do before she considers running, an audience member shouted "Get a facelift!"
Begala was quick with a comeback: "No, not get a facelift. She's not a Republican society lady, she's a real woman."
He then launched into further praises of Clinton's work helping women as the crowd booed.
Watch the entire half-hour debate below or skip ahead to 18:24.
Notable deaths of 2014 [PHOTOS]