The collision occurred while the two buses, carrying approximately 80 passengers, were traveling on the El-Tor-Sharm El-Sheikh freeway en route from Cairo to Sharm El-Sheikh.
An investigation into the cause of the crash is underway although officials have ruled out foul play, South Sinai security directorate head Haaem Amin stated.
South Sinai prosecutor Mohamed Abdel-Salam issued a detention order for the two bus drivers who were injured in the crash. The prosecutor's office reportedly plans to conduct drug tests and question the drivers once their conditions improve.
All those who died in the crash were identified as Egyptian nationals. Four foreign tourists were among the 41 injured: two Saudi nationals, one Yemeni, and one Ukrainian.